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Research Interests of Participating Faculty
Amir Huda, Physics.
In vivo Magnetic Resonance Spectroscopy is a novel tool to look at
the functional biochemistry of the human body in normal and diseased
states. The technology provides a basis to model and interpret the
macroscopic clues manifested as clinical and laboratory findings. It
has been successfully employed in many psychiatric disorders,
metabolic encephalopathies, cancer, and neurological disorders
providing signature changes in levels of metabolites and
neurotransmitters. For the technique to become reliable and routine
in the clinic, it is crucial that the quantitative measures provide
a high degree of accuracy and reproducibility. Towards this end,
absolute quantitation of metabolites seen with spectroscopy is an
area of active interest and research. Dr. Huda is involved with
research that deals with absolute quantification of cerebral
metabolites and standardizing applications in research protocols
involving MR Spectroscopy of the human brain. Besides, the
one-spectral dimensional spectroscopy, newer techniques are being
implemented to adequately identify and quantify overlapping
metabolites so that proper diagnosis can be made on the basis of the
levels analyzed. One such technique is the application of
multidimensional 3D correlated spectroscopy. Dr. M. Albert Thomas at
UCLA is the first to show the implementation of this technique in
hepatic encephalopathy and late-life major depression. Dr. Huda is
involved as a collaborator with Dr. Thomas on these projects.
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