Kin-Ping Wong
Professor of Chemistry, and
Dean, College of Science and Mathematics
Biochemistry

Biographical Information:

• B.S. Chemistry, University of California at Berkeley, 1964
• Ph.D. Physical Chemistry and Biochemistry, Purdue University, Lafayette, Indiana, 1968
• Postdoctoral Fellow, Duke University Medical Center, Durham, North Carolina (with Prof. Charles Tanford), 1970
• Associate Professor of Chemistry, University of South Florida, Tampa, FL, 1975
• Visiting Scientist, Max-Planck Institute for Molecular Genetics, Berlin, Germany), 1972
• Senior Fellow, European Molecular Biology Organization (Uppsala University, Uppsala, Sweden), 1975
• Graduate Courses in Economics, Management, Finance, and Administration (University of Kansas), 1981
• Professor of Biochemistry, University of Kansas, College of Health Sciences, Kansas City, KS, 1983
• Dean of Graduate Studies, University of Kansas, College of  Health Sciences, Kansas City, KS, 1983
• Program Director, National Science Foundation (NSF), Washington, DC, 1984
• Adjunct Professor in the Departments of Medicine and Biochemistry and Biophysics at the University of California, San Francisco Medical School.
• Dr. Wong is also currently the Founder and Chairman of the Board of Angiogen, Inc., a California bio-pharmaceutical development company.

Research Interests:

Dr. Wong's current research focuses on the discovery and development of novel anti-angiogenic therapeutics targeting the vascular network for the treatment of neovascular-based diseases such as cancer and arthritis.

Research Publications:

In the Area of Protein Denaturation-Renaturation and Folding

1. Wong, K.P. and Foster, J.F. "The Microheterogeneity of Plasma Albumin VI. Membrane Equilibrium Salting-Out as a Method of Demonstrating Microheterogeneity of Proteins," Biochemistry 8, 4096 (1969).
2. Wong, K.P. and Foster, J.E. "The Microheterogeneity of Plasma Albumins VII. An Investigation of the Equilibrium Salting-Out Method of the Origins of Microheterogeneity," Biochemistry 8, 4104 (1969).
3. Wong, K.P., Roxby, R., and Tanford, C. "Criteria of Purity for Guanidine Hydrochloride," Analytical Biochemistry 40, 549 (1971).
4. Wong, K.P. and Tanford, C. "Denaturation of Bovine Carbonic Anhydrase B by Guanidine Hydrochloride. A Process Involving Separable Sequential Conformational Transitions," J. Biol. Chem. 248, 8518 (1973).
5. Wong, K.P. and Hamlin, L.M. "The Acid Denaturation of Carbonic Anhydrase," Biochemistry 13, 2678 (1974).
6. Wong, K.P. and Hamlin, L.M. "The Role of Zn(II) on the Folding of Carbonic Anhydrase," Arch. Biochem. Biophys. 170, 12 (1975).
7. Wong, K.P. "Optical Rotatory Dispersion and Circular Dichroism. I. General," J. Chem. Ed. 51, A573-A578 (1974).
8. Wong, K.P. "Optical Rotatory Dispersion and Circular Dichroism. I. Instrumentation," J. Chem. Ed. 52, A9-A16 (1975).
9. Wong, K.P. "Optical Rotatory Dispersion and Circular Dichroism. III. Experimental Aspects," J. Chem. Ed. 52, A83-A88 (1975).
10. Luer, C.A. and Wong, K.P. "The Proteins of Sickle Red Cell Membrane," Biochem. Med. 19, 95-107 (1978).
11. Luer, C.A. and Wong, K.P. "The Effects of Temperature and pH on the Conformation of Proteins in Human Red Cell Membrane," Biophysical Chemistry 9, 15 (1978).
12. McCoy, L.F. and Wong, K.P. "The Denaturation and Renaturation of Cobalt Carbonic Anhydrase B from Bovine Erythrocyte," Biopolymers 18, 2893-2904 (1979).
13. McCoy, L.F. and Wong, K.P.  "The Denaturation of Bovine Erythrocyte Carbonic Anhydrase B Denatured by Acid, Heat, and Detergent," Biochemistry 20, 3062-3067 (1981).
14. Kessler, K., Barth, R., and Wong, K.P.  "Structural Changes of Serum Albumin Upon Dinitrophenylation," International Journal of Protein Chemistry, (1982)
15. Moore, W.V., Wong, K.P., and Rawitch, A.B.  "Conformational Effects of Cations and pH on Human Growth Hormone in Solution," Endorinology 107, 822 (1980).
16. McCoy, L.F., Rowe, E.S., and Wong, K.P.  "Multi-Parameter Kinetic Analyses on the Refolding of Bovine Carbonic Anhydrase B," Biochemistry 19, 4738-4743 (1980).
17. McCoy, L.F. and Wong, K.P.  "The Rationalization and Construction of a Molecular Model of Bovine Carbonic Anhydrase B" (manuscript in preparation).
18. McLinden, J., Wong, K.P., Murdock, A.L., and Amelunxen, R.E.  "Conformational Studies on the Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase From the Facultative Thermophile Bacillus coagulans KU," Arch. Biochem. Biophysics 233, 299-309 (1984).
    
    In the Area of Protein Synthesis-Ribosome
    
19. Wong, K.P., Dunn, J.M., and Binford, J.S., Jr.  "A Microcalorimetric Study of the Unfolding of Ribosome," FEBS Letters (Federation of Europ. Biochem. Soc.) 41, 211 (1974).
20. Wong, K.P. and Dunn, J.M.  "A Conformational Study on the Unfolding of Ribosome," FEBS Letters (Federation of Europ. Biochem. Soc.) 44, 50-54 (1974).
21. Wong, K.P. and Paradies, H.  "Physical Biochemical Studies of Ribosomal Proteins I.  The Shape and Subunit Structure of Protein L7/L12," Biochem. Biophys. Res. Comm. 61, 178-184 (1974).
22. Allen, S.H. and Wong, K.P.  "The Conformation of E. coli Ribosomal Proteins Free in Solution and Bound to Ribosomal RNA," Biochemistry 17, 3971 (1978).
23. Fox, J.W., Owens, D.P., and Wong, K.P.  "Structural Changes of Ribosome by the Action of Ethylene Glycol," Biochemistry 17, 1257 (1978).
24. Allen, S.H. and Wong, K.P.  "The Conformation of Protein S4 from E. coli Ribosome," Biophys. J. 23, 1359 (1978).
25. Fox, J.W. and Wong, K.P.  "Conformational Change of 5S RNA Upon Protein Binding," J. Biol. Chem. 253, 18 (1978).
26. Allen, S.H. and Wong, K.P.  "The Shape and Conformation of Ribosomal 16S RNA Free in Solution and Bound in the 30S Subunit," J. Biol. Chem. 253, 8759 (1978).
27. Luer, C.A. and Wong, K.P.  "Conformation Studies of Protein L7/L12 from E. coli Ribosome," Biochemistry 10, 2019 (1979).
28. Dunn, J.M. and Wong, K.P.  "Conformational Changes of 16S RNA During the Self-Assembly of the 30S Ribosomal Subunit from E. coli," J. Biol. Chem. 254, 7705-7711 (1979).
29. Dunn, J.M. and Wong, K. P.  "Conformational Changes of Proteins During the Self-Assembly of the 30S Ribosomal Subunit from E. coli," J. Biol. Chem. 254, 7712-7716 (1979).
30. Allen, S.H. and Wong, K.P.  "A Comparative Circular Dichroism and Sedimentation Velocity Study of Ribosomal 16S RNA and 16S RNA-Protein S4 Complex Under the Conditions of Reconstitution," J. Biol. Chem. 254, 1775 (1979).
31. Dunn, J.M. and Wong, K.P.  "The Structure and Stability of the Reconstituted Intermediate Particles Involved in the Self-Assembly of E. coli Ribosome," Biochemistry 18, 4380-4385 (1979).
32. Allen, S.H. and Wong, K.P.  "The Shape and Conformation of E. coli Ribosome and its Subunits in Reconstitution Buffer," Arch. Biochem. Biophys. 195, 112 (1979).
33. Owens, D.P., Fox, J.W., and Wong, K.P.  "Densities, Viscosities, and Refractive Indexes of Ethylene Glycol Solutions and Tris-Mg(II)-KCl Buffers," Biochem. Biophys. Res. Comm. 96, 685-691 (1980).
34. Fox, J.W. and Wong, K.P.  "The Structure of Ribosomal 5S RNA from E. coli:  Hydrodynamic Shape, Conformation, Stability, and Molecular Model," J. Biol. Chem. 254, 10139-10144 (1979).
35. Owens, D.P., Fox, J.W., and Wong, K.P.  "Circular Dichroism Analysis of the Secondary Structure of E. coli Ribosomal 5S RNA by Two Computer Approaches," Biopolymers (submitted) .
36. Owens, D.P., Van Duin, J., and Wong, K.P.  "Interactions of Ribosomal Protein S1 with 16S RNA and S1-Deficient 30S Subunit," Biochemistry (submitted).
37. Allen, S.H. and Wong, K.P.  "The Role of Mg2+ Ion on the Hydrodynamic Shape and Conformation of Ribosomal 16S RNA," Arch. Biochem. Biophys. 249, 137-147 (1986).
38. Fox, J.W. and Wong, K.P.  "The Acquisition of Native Conformation of 5S RNA from E. coli Ribosome," Biochemistry 21, 2096-2102 (1982).
39. Fox, J.W. and Wong, K.P.  "The Purification and Circular Dichroism Studies of Ribosomal 5S RNA Binding Protein L25" (submitted to Arch. Biochem. Biophys.) .
40. Luer, C.A. and Wong, K.P.  "Conformational Stability of Ribosomal Protein L7/L12," Biochemistry 19, 176-183 (1980).
41. Luer, C.A. and Wong, K.P.  "The Interaction of Ribosomal Proteins L7/L12 with L10" (manuscript in preparation).
42. Dunn, J.M., McCoy, L.F., and Wong, K.P.  "Denaturation Studies of Concanavalin A" (manuscript submitted to BBA) .
43. Yi, Q.M. and Wong, K.P.  "The Role of Magnesium Ions on the Hydrodynamic Properties, Conformation, and Stability of Ribosomal 23S RNA," Biochem. Biophys. Res. Comm. 104, 733-739 (1982)
44. Wang, A. and Wong, K.P.  "The Acquisition of Native Conformation of Ribosomal 16S RNA.  I.  Characterization of the Unfolded Conformation and Refolding of the Secondary Structure" (manuscript submitted to Biochemistry).
45. Hung, C.H. and Wong, K.P.  "The Acquisition of Native Conformation of Ribosomal 16S RNA.  II.  Tertiary Structure of the Refolded RNA and its Reconstitution to 30S Subunit" (manuscript submitted to Biochemistry).
46. Nguyen, L.S. and Wong, K.P.  "Molecular Mechanism of the Assembly of 50S Ribosomal Subunit from E. coli" (manuscript in preparation).
47. Nguyen, L.S. and Wong, K.P.  "Formation of the Ribosomal 23S RNA from E. coli" (manuscript submitted).
48. Simpson, B.E. and Wong, K.P.  "The Role of Polyamines on the Structure of Ribosomal 16S RNA" (manuscript submitted).
49. Fox, J.W., Owens, D.P., and Wong, K.P.  "Purification and Conformation of Ribosomal Protein L25 from E. Coli Ribosome."  Int. J. Peptide Prot. Res. 31, 255-264 (1988)
50. Corton, J.C. and Wong, K.P.  "The Conformation and Stability of Ribosomal Protein S7."  International Journal of Peptides and Proteins (In Press) (1989).
51. Corton, J.C. and Wong, K.P.  "The Prediction of a Three-Dimensional Model of Ribosomal Protein S7."  International Journal of Peptides and Proteins (In Press) (1989).
52. Corton, J.C. and Wong, K.P.  "The Structural Domains of Ribosomal Protein L7/L12:  Proteolytic Dissection and Characterization of Fragments"  (manuscript submitted to Biochemistry) (1989).
53. Schulz, W., Ewy, R. and Wong, K.P.  "Isolation and Purificaiton of an Angiogenesis Inhibitor from Shark Cartilage."  Biochem. Biophys. Res. Comm. (Submitted) (1990)
54. Wong, K.P., Wong, A., and Khoo, L.  "Conformation and Stability of Shark Cartilage Angiogenesis Inhibitor." (manuscript in preparation) (1990)
55. Ikai, Atsushi, Mitsui, Keita, Furutani, Yutaka, Hara, Masahiko, McMurty, John and Wong, K.P.  “Protein Stretching II:  Results for Carbonic Anhydrase.”  Jpn. J. Appl. Phys. Vol. 36, 3887-3893 (1997)
56. Wong, Kin-Ping and Liang, Jeannie, Advances in  Angiogenesis: From the Molecular to the Integrative Pharmacology,  209-223 (2000)
    
    Published Books and Treatises
    
57. Wong, Kin-Ping and Wen-Ren, Jun, “The History of Science and Technology in China”, 631pp (1999)
58. Wong, Kin-Ping and Wen-Ren, Jun, “A Photographic Illustration on the History of Science and Technology in China”, (To be published in 2003)

Address:

Dr. Kin-Ping Wong
California State University, Fresno
College of Science and Mathematics
Fresno, CA 93740
Phone: (559) 278-3936
kinpingw@csufresno.edu

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